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Editorial
. 2019 Aug 28;20(1):179.
doi: 10.1186/s13059-019-1800-6.

Night science

Affiliations
Editorial

Night science

Itai Yanai et al. Genome Biol. .
No abstract available

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The popping-out model of day science and night science. Day thinking proceeds in logical steps, and thus only ideas that are closely related to the current hypothesis can realistically be reached (symbolized by the isolated valleys in the lower part of the picture). But one can pop out to the much more open night science world, where leaps among ideas are made possible by intuition, associative thinking, unexplained observations, and loosely applied principles from other fields. When a new idea has been generated, one can pop back into the day below and test it efficiently using day science methods

References

    1. Yanai I, Korbel JO, Boue S, McWeeney SK, Bork P, Lercher MJ. Similar gene expression profiles do not imply similar tissue functions. Trends Genet. 2006;22:132–138. doi: 10.1016/j.tig.2006.01.006. - DOI - PubMed
    1. Yanai I, Graur D, Ophir R. Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control. OMICS. 2004;8:15–24. doi: 10.1089/153623104773547462. - DOI - PubMed
    1. Jacob F. The statue within: an autobiography. New York: Cold Spring Harbor Laboratory Press; 1988.
    1. Hashimshony T, Feder M, Levin M, Hall BK, Yanai I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature. 2015;519:219–222. doi: 10.1038/nature13996. - DOI - PMC - PubMed
    1. Levin M, Anavy L, Cole AG, Winter E, Mostov N, Khair S, et al. The mid-developmental transition and the evolution of animal body plans. Nature. 2016;531:637–641. doi: 10.1038/nature16994. - DOI - PMC - PubMed

Publication types

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