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. 2020 Feb;22(2):292-300.
doi: 10.1038/s41436-019-0635-6. Epub 2019 Aug 29.

The cost trajectory of the diagnostic care pathway for children with suspected genetic disorders

Collaborators, Affiliations
Free article

The cost trajectory of the diagnostic care pathway for children with suspected genetic disorders

Nick Dragojlovic et al. Genet Med. 2020 Feb.
Free article

Abstract

Purpose: This study describes the cost trajectory of the standard diagnostic care pathway for children with suspected genetic disorders in British Columbia, Canada.

Methods: Average annual per-patient costs were estimated using medical records review and a caregiver survey for a cohort of 498 children referred to BC Children's and Women's Hospitals (C&W) with unexplained intellectual disability (the TIDE-BC study) and families enrolled in the CAUSES study, which offered diagnostic genome-wide sequencing (GWS; exome and genome sequencing) to 500 families of children with suspected genetic disorders.

Results: Direct costs peaked in the first year of patients' diagnostic odyssey, with an average of C$2257 per patient (95% confidence interval [CI] C$2074, C$2441) for diagnostic testing and C$631 (95% CI C$543, C$727) for specialist consultations at C&W. In subsequent years, direct costs accrued at a constant rate, with an estimated annual per-patient cost of C$511 (95% CI C$473, C$551) for diagnostic testing and C$334 (95% CI C$295, C$369) for consultations at C&W. Travel costs and caregiver productivity loss associated with attending diagnosis-related physician appointments averaged C$1907/family/year.

Conclusions: The continuing long-term accrual of costs by undiagnosed patients suggests that economic evaluations of diagnostic GWS services should use longer time horizons than have typically been used.

Keywords: cost trajectory; diagnostic costs; diagnostic pathway; genetic disorders; genome-wide sequencing.

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References

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