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Review
. 2019 Aug 19;5(8):e02192.
doi: 10.1016/j.heliyon.2019.e02192. eCollection 2019 Aug.

Challenges of intervention, treatment, and antibiotic resistance of biofilm-forming microorganisms

Gebreselema Gebreyohannes  1   2 , Andrew Nyerere  3 , Christine Bii  4 , Desta Berhe Sbhatu  1
Affiliations
Review

Challenges of intervention, treatment, and antibiotic resistance of biofilm-forming microorganisms

Gebreselema Gebreyohannes et al. Heliyon. .

Abstract

Background: Biofilms are multicellular communities of microorganisms held together by a self-produced extracellular matrix. The ability of microbes to form biofilm is a universal, ubiquitous, and dynamic process. This dynamic process of biofilms establishes an important strategy to withstand and survive harsh environmental conditions and antimicrobial agents.

Objective: This review paper aims to give an overview of antibiotic resistance, intervention, and treatment of infections caused by biofilm-forming organisms. Moreover, it can also help to motivate scholars to search for new anti-biofilm strategies and most appropriate methods to tackle the effect of biofilm infections on healthcare services.

Methods: This paper was written by reviewing recent research and review articles which are reporting about the antibiotic resistance, prevention, and treatment of biofilm-producing organisms.

Conclusion: Bioprospecting for quorum quenching compounds can be an appropriate solution for controlling biofilm infections.

Keywords: Antibiotic resistance; Biofilms; Intervention; Microbiology; Quorum sensing; Treatment.

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