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. 2019 Aug 20;5(8):e02318.
doi: 10.1016/j.heliyon.2019.e02318. eCollection 2019 Aug.

Synthesis of novel Schiff bases containing arylpyrimidines as promising antibacterial agents

Soukhyarani Gopal Nayak  1 , Boja Poojary  1
Affiliations

Synthesis of novel Schiff bases containing arylpyrimidines as promising antibacterial agents

Soukhyarani Gopal Nayak et al. Heliyon. .

Abstract

Pursuing our recent interest regarding the antimicrobial activity of Schiff bases derivatives, we have synthesized a series of 6-(substitutedphenyl)-N'-((E)-(substitutedphenyl)methylidene)-2-methylpyridine-3-carbohydrazides (5a-n) and evaluated their antibacterial activity. Structures of these compounds were confirmed by standard studies of FTIR, 1H NMR, 13C NMR, MS and elemental analysis. Antibacterial activity of synthesized molecules was tested against Gram-positive (S. aureus and E. faecalis) and Gram-negative (E. coli and P. aeruginosa) bacterial strains. Synthesized compounds showed good antibacterial activity at a lower concentration than standard. Most of the compounds (5a, 5c, 5i, 5j and 5n) are potent against all the tested bacterial strains with MIC values ranging from 1.56-12.5 μg/mL.

Keywords: Antimicrobial activity; Electron donating; Materials chemistry; Natural product chemistry; Organic chemistry; Pharmaceutical chemistry; Pyridine; Schiff bases.

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Figures

Fig. 1
Fig. 1
Bioactive pyridinehydrazone and Schiff base derivatives.
Fig. 2
Fig. 2
Outline for the synthesis. Reagents and conditions: (i) DMF-DMA, 90 °C, 5–6 h (ii) Ethyl acetoacetate, NH4OAc, AcOH, reflux, 3 h (iii) N2H4, reflux, 5–6 h (iv) Substituted aromatic aldehydes, AcOH, ethanol, reflux, 5 h.
Fig. 3
Fig. 3
Graphical representation of antibacterial studies of the target compounds against four bacterial strains.
See this image and copyright information in PMC

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