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. 2020 Aug;13(4):528-530.
doi: 10.1007/s12265-019-09910-4. Epub 2019 Aug 28.

Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

Marat Fudim  1   2 , Vanessa L Blumer  3 , Renato D Lopes  4 , Patrick Rossignol  5 , Michael Feldschuh  6 , Wayne L Miller  7 , Paul A Sobotka  8
Affiliations

Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

Marat Fudim et al. J Cardiovasc Transl Res. 2020 Aug.

Abstract

Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from - 23 to + 28% for TBV, - 22 to + 36% for PV and - 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = - 0.03; PV and SBP, r = - 0.12; RBV and SBP, r = - 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.

Keywords: Blood volume analysis; Gender; Hypertension; Race.

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Figures

Figure 1:
Figure 1:
Blood volume analysis in patients with hypertension. A- Deviation of total blood volume from ideal. B- Correlation between blood volume and systolic blood pressure. Race based blood volume analysis. Deviation from ideal C- Total blood volume, D- Plasma Volume, and E- Red Blood Cell Volume, stratified by race (Blacks vs. White/Hispanic/Asian).
See this image and copyright information in PMC

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