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. 2019 Oct 1;14(19):3269-3273.
doi: 10.1002/asia.201901078. Epub 2019 Sep 10.

Visible-Light-Promoted Cascade Radical Cyclization: Synthesis of 1,4-Diketones Containing Chroman-4-One Skeletons

Xiang-Kui He  1 , Bao-Gui Cai  1 , Qing-Qing Yang  2 , Long Wang  2 , Jun Xuan  1   3
Affiliations

Visible-Light-Promoted Cascade Radical Cyclization: Synthesis of 1,4-Diketones Containing Chroman-4-One Skeletons

Xiang-Kui He et al. Chem Asian J. .

Abstract

A visible-light-induced cascade radical cyclization of aroyl chlorides with 2-(allyloxy)-benzaldehyde derivatives has been developed. The method takes advantages of unactivated C=C bonds as the acyl radical acceptors and offers a mild and green approach for the synthesis of 1,4-diketones bearing biologically important chroman-4-one skeletons with moderate to good yields.

Keywords: 1,4-Diketones; Acyl radical; Photoredox catalysis; Radical cyclization; Visible light.

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References

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