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Comment
. 2019 Aug;15(8):e9059.
doi: 10.15252/msb.20199059.

Reply to "CRISPR screens are feasible in TP53 wild-type cells"

Emma Haapaniemi  1 , Sandeep Botla  1 , Jenna Persson  1   2 , Bernhard Schmierer  1   2 , Jussi Taipale  1   3   4
Affiliations
Comment

Reply to "CRISPR screens are feasible in TP53 wild-type cells"

Emma Haapaniemi et al. Mol Syst Biol. 2019 Aug.

Abstract

Haapaniemi et al address the issues raised by Brown et al and discuss several differences between the analyses performed by the two groups.

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References

    1. Cullot G, Boutin J, Toutain J, Prat F, Pennamen P, Rooryck C, Teichmann M, Rousseau E, Lamrissi‐Garcia I, Guyonnet‐Duperat V et al (2019) CRISPR‐Cas9 genome editing induces megabase‐scale chromosomal truncations. Nat Commun 10: 1136 - PMC - PubMed
    1. Geisinger JM, Stearns T (2019) CRISPR/Cas9 treatment causes Extended TP53‐dependent cell cycle arrest in human cells. bioRxiv 10.1101/604538 [PREPRINT] - DOI - PMC - PubMed
    1. Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J (2018) CRISPR–Cas9 genome editing induces a p53‐mediated DNA damage response. Nat Med 24: 927–930 - PubMed
    1. Ihry RJ, Worringer KA, Salick MR, Frias E, Ho D, Theriault K, Kommineni S, Chen J, Sondey M, Ye C et al (2018) p53 inhibits CRISPR‐Cas9 engineering in human pluripotent stem cells. Nat Med 24: 939–946 - PubMed
    1. Kosicki M, Tomberg K, Bradley A (2018) Repair of double‐strand breaks induced by CRISPR‐Cas9 leads to large deletions and complex rearrangements. Nat Biotechnol 36: 765–771 - PMC - PubMed

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