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Review
. 2019 Oct;33(5):873-885.
doi: 10.1016/j.hoc.2019.05.012. Epub 2019 Jul 5.

Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

Thomas G Scorer  1 , Kristin M Reddoch-Cardenas  2 , Kimberly A Thomas  3 , Andrew P Cap  2 , Philip C Spinella  3
Affiliations
Review

Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

Thomas G Scorer et al. Hematol Oncol Clin North Am. 2019 Oct.

Abstract

Bleeding related to thrombocytopenia is common in hematology-oncology patients. Platelets stored at room temperature (RTPs) are the current standard of care. Platelets stored in the cold (CSPs) have enhanced hemostatic function relative to RTPs. CSPs were reported to reduce bleeding in hematology-oncology patients. Recent studies have confirmed the enhanced hemostatic properties of CSPs. CSPs may be the better therapeutic option for this population. CSPs may also offer a preferable immune profile, reduced thrombotic risk, and reduced transfusion-transmitted infection risk. The logistical advantages of CSPs would improve outcomes for many patients who currently cannot access platelet transfusions.

Keywords: Bleeding; Cold-stored platelets; Oncology; Platelet storage; Platelet transfusion; Thrombocytopenia.

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