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Comment
. 2019 Oct;9(10):1331.
doi: 10.1158/2159-8290.CD-NB2019-100. Epub 2019 Aug 29.

Gone Wildling: Building a Better Lab Mouse

No authors listed
Comment

Gone Wildling: Building a Better Lab Mouse

No authors listed. Cancer Discov. 2019 Oct.

Abstract

By implanting wild female mice with common lab mouse embryos, researchers created a "wildling" model that combines natural microbiota with tractable genetics and, as a result, may improve the value of translational research.

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  • Laboratory mice born to wild mice have natural microbiota and model human immune responses.
    Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I, Collins N, Blatter JA, Han SJ, Tamoutounour S, Potapova S, Foster St Claire MB, Yuan W, Sen SK, Dreier MS, Hild B, Hafner M, Wang D, Iliev ID, Belkaid Y, Trinchieri G, Rehermann B. Rosshart SP, et al. Science. 2019 Aug 2;365(6452):eaaw4361. doi: 10.1126/science.aaw4361. Epub 2019 Aug 1. Science. 2019. PMID: 31371577 Free PMC article.

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