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A 62-year-old man was admitted to the emergency department due to fever and acute heart failure. A transthoracic echocardiogram revealed severe aortic valve obstruction. He was an hepatic transplant recipient and was medicated with everolimus. He underwent mitral and aortic valve replacement with prosthetic valves 4 years ago. Due to his medical background, therapy and clinical presentation, empirical therapy for infective endocarditis was started. Transoesophageal echocardiogram showed severe aortic valve regurgitation but no other findings suggestive of endocarditis. Computed tomography (CT) revealed pulmonary infiltrates compatible with infection and no evidence of septic embolisation. Multiple sets of blood cultures were negative. Proteus mirabilis was isolated in bronchial lavage and antibiotic therapy was adjusted. The patient underwent aortic valve replacement, with no macroscopic findings suggestive of endocarditis. P. mirabilis was isolated in the surgically removed valve. Dual antibiotic therapy was successfully administered for 6 weeks.
Transoesophageal echocardiogram of the aortic prosthetic valve. 1- Transoesophageal view of the aortic…
Figure 1
Transoesophageal echocardiogram of the aortic prosthetic valve. 1- Transoesophageal view of the aortic valve with colour Doppler showing severe regurgitation. 2- Transgrastric view. 3- Aortic valve with thickened cusps. Colour Doppler showing intravalvular and paravalvular regurgitant jets.
Tleyjeh IM, Abdel-Latif A, Rahbi H, et al. A systematic review of population-based studies of infective endocarditis. Chest 2007;132:1025–35. 10.1378/chest.06-2048
-
DOI
-
PubMed
Ambrosioni J, Hernandez-Meneses M, Téllez A, et al. The changing epidemiology of infective endocarditis in the twenty-first century. Curr Infect Dis Rep 2017;19 10.1007/s11908-017-0574-9
-
DOI
-
PubMed
Selton-Suty C, Célard M, Le Moing V, et al. Preeminence of Staphylococcus aureus in infective endocarditis: a 1-year population-based survey. Clin Infect Dis 2012;54:1230–9. 10.1093/cid/cis199
-
DOI
-
PubMed
Murdoch DR, Corey GR, Hoen B, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med 2009;169:463-73 10.1001/archinternmed.2008.603
-
DOI
-
PMC
-
PubMed
Ruttmann E, Bonatti H, Legit C, et al. Severe endocarditis in transplant recipients—an epidemiologic study. Transplant International 2005;18:690–6. 10.1111/j.1432-2277.2005.00120.x
-
DOI
-
PubMed