Conflict of interest: F.C. Ringshausen reports grants, personal fees for consultancy and lectures, and support for educational activities from Bayer HealthCare and Grifols Germany, grants, personal fees for consultancy and lectures, support for educational activities and clinical trial participation from Insmed Germany and Novartis, personal fees for consultancy and lectures from AstraZeneca, personal fees for lectures, support for educational activities and clinical trial participation from from Chiesi and Boehringer Ingelheim, grants and support for educational activities from InfectoPharm, support for clinical trial participation from Vertex, Parion, Celtaxsys, Corbus and Algipharma, support for educational activities and clinical trial participation from from GSK, grants from Polyphor and Baslilea, personal fees for consultancy and support for clinical trial participation from Zambon, outside the submitted work. Conflict of interest: J. Rademacher reports grants and personal fees from Bayer Health Care, Insmed and Grifols, personal fees from MSD Sharp & Dohme, AstraZeneca and Chiesi, outside the submitted work. Conflict of interest: I. Pink reports grants from Infectopharm, Bayer, Insmed and Grifols, during the conduct of the study; personal fees and non-financial support from Berlin Chemie, Boehringer Ingelheim and Chiesi, outside the submitted work. Conflict of interest: A. de Roux has nothing to disclose. Conflict of interest: L. Hickstein has nothing to disclose. Conflict of interest: T. Ploner has nothing to disclose. Conflict of interest: T. Welte reports grants and personal fees for lectures from Grifols, Insmed and Novartis, outside the submitted work. Conflict of interest: R. Diel reports grants and personal fees from Bayer Vital, personal fees from Insmed Inc., outside the submitted work.