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. 2019 Dec;16(12):940-942.
doi: 10.1038/s41423-019-0275-4. Epub 2019 Aug 29.

CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

Joana Vitallé  1 , Iñigo Terrén  1 , Ane Orrantia  1 , Raquel Pérez-Garay  1 , Francesc Vidal  2 , José A Iribarren  3 , Carmen Rodríguez  4 , Ana M López Lirola  5 , Enrique Bernal  6 , Olatz Zenarruzabeitia  1 , Francisco Borrego  7   8
Affiliations

CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

Joana Vitallé et al. Cell Mol Immunol. 2019 Dec.
No abstract available

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Degranulation and cytokine production by NK cells in response to the cocrosslinking of CD16 and CD300a. a Zebra plots showing the percentage of CD56dim NK cells positive for CD107a, IFNγ, MIP-1β, and TNF from a representative untreated HIV-1 infected patient after stimulation with isotype control, anti-CD16 plus isotype control, or anti-CD16 plus anti-CD300a mAbs. b Bar graphs showing the percentage of CD56bright, CD56dim, and CD56neg NK cells positive for CD107a, IFNγ, MIP-1β, and TNF from healthy donors (HD), untreated HIV-1 infected subjects (HIV), and subjects under cART (HIV ART) after stimulation with isotype control, anti-CD16 plus isotype control, or anti-CD16 plus anti-CD300a mAbs. The mean with the SEM is represented. c Dot plots showing the percentage of CD300a-mediated inhibition of degranulation (CD107a) and MIP-1β production by CD56bright, CD56dim, and CD56neg NK cells, comparing HD, HIV, and HIV ART patients. Each dot represents a subject, and the median is shown. *p < 0.05, **p < 0.01, ***p < 0.001
See this image and copyright information in PMC

References

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