Screen time: studying gene function in iPSCs

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Katherine Whalley. Nat Rev Neurosci. 2019 Oct.

. 2019 Oct;20(10):573.

doi: 10.1038/s41583-019-0217-2.

No abstract available

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A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.
Kwart D, Gregg A, Scheckel C, Murphy EA, Paquet D, Duffield M, Fak J, Olsen O, Darnell RB, Tessier-Lavigne M. Kwart D, et al. Neuron. 2019 Oct 23;104(2):256-270.e5. doi: 10.1016/j.neuron.2019.07.010. Epub 2019 Aug 12. Neuron. 2019. PMID: 31416668
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.
Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M. Tian R, et al. Neuron. 2019 Oct 23;104(2):239-255.e12. doi: 10.1016/j.neuron.2019.07.014. Epub 2019 Aug 15. Neuron. 2019. PMID: 31422865 Free PMC article.

1. Tian, R. et al. CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons. Neuron https://doi.org/10.1016/j.neuron.2019.07.014 (2019) - DOI - PubMed
1. Kwart, D. et al. A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP β-CTFs, not Aβ. Neuron https://doi.org/10.1016/j.neuron.2019.07.010 (2019) - DOI - PubMed