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. 2019 Jul 28:2019:8391263.
doi: 10.1155/2019/8391263. eCollection 2019.

Chemical Investigation of a Biologically Active Schinus molle L. Leaf Extract

Stefania Garzoli  1 , Valentina Laghezza Masci  2 , Elisa Ovidi  2 , Giovanni Turchetti  2 , Daniele Zago  2 , Antonio Tiezzi  2
Affiliations

Chemical Investigation of a Biologically Active Schinus molle L. Leaf Extract

Stefania Garzoli et al. J Anal Methods Chem. .

Abstract

The pepper tree Schinus molle L. is an evergreen ornamental plant belonging to the Anacardiaceae family, native to South America and widespread throughout the world. It has biological activities and is used in folk medicine. This paper aims to contribute to a deeper knowledge of its chemical composition and biological properties. S. molle leaf extracts were obtained by sequential extraction with solvents of different polarities and subsequently tested on the HL-60 human leukaemia cell line to define a possible cytotoxic activity. Among the investigated extracts, the petroleum ether extract revealed a high cytotoxic activity, and its chemical composition was further investigated. By a silica column chromatography, eight fractions were obtained, and their compositions were determined by GC-MS analysis. Compounds and relative abundance differed widely among the fractions; sesquiterpenes resulted the main component and alcoholic sesquiterpenes the most abundant.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

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