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Review
. 2019 Jul 29:2019:3469754.
doi: 10.1155/2019/3469754. eCollection 2019.

Are There Potential Applications of Fecal Microbiota Transplantation beyond Intestinal Disorders?

Affiliations
Review

Are There Potential Applications of Fecal Microbiota Transplantation beyond Intestinal Disorders?

Youlian Zhou et al. Biomed Res Int. .

Abstract

Intestinal microbial dysbiosis is associated with various intestinal and extraintestinal disorders. Fecal microbiota transplantation (FMT), a type of fecal bacteriotherapy, is considered an effective therapeutic option for recurrent Clostridium difficile infection (rCDI) and also has important value in other intestinal diseases including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). The purpose of this review is to discuss promising therapeutic value in extraintestinal diseases associated with gut microbial dysbiosis, including liver, metabolic, chronic kidney, neuropsychiatric, allergic, autoimmune, and hematological diseases as well as tumors.

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Conflict of interest statement

The authors declare that they have no conflicts of interest or competing financial interests.

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References

    1. Khanna S., Tosh P. K. A clinician's primer on the role of the microbiome in human health and disease. Mayo Clinic Proceedings. 2014;89(1):107–114. doi: 10.1016/j.mayocp.2013.10.011. - DOI - PubMed
    1. Yatsunenko T., Rey F. E., Manary M. J., et al. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222–227. doi: 10.1038/nature11053. - DOI - PMC - PubMed
    1. Maynard C. L., Elson C. O., Hatton R. D., Weaver C. T. Reciprocal interactions of the intestinal microbiota and immune system. Nature. 2012;489(7415):231–241. doi: 10.1038/nature11551. - DOI - PMC - PubMed
    1. Benson A. K., Kelly S. A., Legge R., et al. Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proceedings of the National Acadamy of Sciences of the United States of America. 2010;107(44):18933–18938. doi: 10.1073/pnas.1007028107. - DOI - PMC - PubMed
    1. Eckburg P. B., Bik E. M., Bernstein C. N., et al. Microbiology: diversity of the human intestinal microbial flora. Science. 2005;308(5728):1635–1638. doi: 10.1126/science.1110591. - DOI - PMC - PubMed

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