Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Dec;20(12):1759-1770.
doi: 10.1111/obr.12940. Epub 2019 Aug 30.

Impact of bariatric surgery on serum uric acid levels and the incidence of gout-A meta-analysis

Charleen Yeo  1 , Sanghvi Kaushal  1 , Beatrice Lim  2 , Nicholas Syn  2 , Aung Myint Oo  1 , Jaideepraj Rao  1 , Aaryan Koura  1 , Danson Yeo  1
Affiliations
Review

Impact of bariatric surgery on serum uric acid levels and the incidence of gout-A meta-analysis

Charleen Yeo et al. Obes Rev. 2019 Dec.

Abstract

Gout is characterized by high serum uric acid (SUA) levels and arthritis. It is associated with obesity and metabolic syndrome. Bariatric surgery has been associated with decreased SUA levels and overall gout incidence. This meta-analysis aims to summarize the current evidence on bariatric surgery, gout and SUA levels. A literature review was performed on papers published from 2000 up till December 2018. Original studies investigating the impact of bariatric surgery on SUA levels or gout incidence were evaluated. Twenty studies with a total of 5,233 patients were analysed. Majority (n=14) had a follow-up duration of at least 12 months. The mean preoperative body mass index (BMI) was 45.2kg m-2 . The mean preoperative SUA level was 6.5mg dL-1 . Subgroup analysis demonstrated a mean decrease in SUA levels (-0.73mg dL-1 ) from the third postoperative month onwards, which was sustained until the third postoperative year (-1.91mg dL-1 ). There was a rise in SUA levels in the first post-operative month. Meta-regression analyses demonstrated a proportionate linear relationship between the change in BMI and SUA levels. Post-bariatric surgery weight loss is associated with reduced SUA levels and decreased incidence of gout attacks. However, this is only evident from the third post-operative month onwards.

Keywords: bariatric surgery; gout; urate; uric acid.

PubMed Disclaimer

References

REFERENCES

    1. Benedek TG, Rodnan GP. A brief history of the rheumatic diseases. Bull Rheum Dis. 1982;32(6):59-68.
    1. Richette P, Bardin T. Gout. Lancet (London, England). 2010;375(9711):318-328.
    1. Nielsen SM, Bartels EM, Henriksen M, et al. Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies. Ann Rheum Dis. 2017;76(11):1870-1882.
    1. Choi HK, Ford ES, Li C, Curhan G. Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2007;57(1):109-115.
    1. Puig JG, Martinez MA. Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol. 2008;20(2):187-191.

LinkOut - more resources