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Review
. 2020 Jan;44(1):36-50.
doi: 10.1002/cbin.11222. Epub 2019 Sep 18.

Experimental models of maternal-fetal interface and their potential use for nanotechnology applications

Thádia Evelyn de Araújo  1 , Iliana Claudia Balga Milián  1 , Guilherme de Souza  1 , Rafaela José da Silva  1 , Alessandra Monteiro Rosini  1 , Pâmela Mendonça Guirelli  1 , Priscila Silva Franco  1 , Bellisa Freitas Barbosa  1 , Eloisa Amália Vieira Ferro  1 , Idessania Nazareth da Costa  1   2
Affiliations
Review

Experimental models of maternal-fetal interface and their potential use for nanotechnology applications

Thádia Evelyn de Araújo et al. Cell Biol Int. 2020 Jan.

Abstract

During pregnancy, the placenta regulates the transfer of oxygen, nutrients, and residual products between the maternal and fetal bloodstreams and is a key determinant of fetal exposure to xenobiotics from the mother. To study the disposition of substances through the placenta, various experimental models are used, especially the perfused placenta, placental villi explants, and cell lineage models. In this context, nanotechnology, an area of study that is on the rise, enables the creation of particles on nanometric scales capable of releasing drugs aimed at specific tissues. An important reason for furthering the studies on transplacental transfer is to explore the potential of nanoparticles (NPs), in new delivery strategies for drugs that are specifically aimed at the mother, the placenta, or the fetus and that involve less toxicity. Due to the fact that the placental barrier is essential for the interaction between the maternal and fetal organisms as well as the possibility of NPs being used in the treatment of various pathologies, the aim of this review is to present the main experimental models used in studying the maternal-fetal interaction and the action of NPs in the placental environment.

Keywords: drug delivery systems; experimental models; maternal-fetal interaction; nanoparticles; placenta.

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References

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