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Editorial
. 2020 Jan;72(1):4-6.
doi: 10.1002/art.41092.

When Randomized Clinical Trials and Real-World Evidence Say the Same: Tocilizumab and Its Cardiovascular Safety

Seoyoung C Kim  1 , Sebastian Schneeweiss  1
Affiliations
Editorial

When Randomized Clinical Trials and Real-World Evidence Say the Same: Tocilizumab and Its Cardiovascular Safety

Seoyoung C Kim et al. Arthritis Rheumatol. 2020 Jan.
No abstract available

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References

    1. Giles JT, Sattar N, Gabriel S, Ridker PM, Gay S, Warne C, et al. Cardiovascular safety of tocilizumab versus etanercept in rheumatoid arthritis: a randomized controlled trial. Arthritis Rheumatol 2019;72:31-40.
    1. US Food and Drug Administration. Framework for FDA's real-world evidence program. December 2018. URL: https://www.fda.gov/media/120060/download.
    1. Kim SC, Solomon DH, Rogers JR, Gale S, Klearman M, Sarsour K, et al. Cardiovascular safety of tocilizumab versus tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a multi-database cohort study. Arthritis Rheumatol 2017;69:1154-64.
    1. Xie F, Yun H, Levitan EB, Muntner P, Curtis JR. Tocilizumab and the risk of cardiovascular disease: direct comparison among biologic disease-modifying antirheumatic drugs for rheumatoid arthritis patients. Arthritis Care Res (Hoboken) 2019;71:1004-18.
    1. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). Guidance for industry: diabetes mellitus-evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. December 2008. URL: https://www.fda.gov/media/71297/download.

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