Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2019;30(5):251-257.
doi: 10.5830/CVJA-2019-015. Epub 2019 Aug 30.

The effects of HIV/AIDS on the clinical profile and outcomes post pericardiectomy of patients with constrictive pericarditis: a retrospective review

D P Naidoo  1 , G Laurence  2 , B Sartorius  3 , S Ponnusamy  2
Affiliations
Comparative Study

The effects of HIV/AIDS on the clinical profile and outcomes post pericardiectomy of patients with constrictive pericarditis: a retrospective review

D P Naidoo et al. Cardiovasc J Afr. 2019.

Abstract

Objective: The clinical profile and surgical outcomes of patients with constrictive pericarditis were compared in HIV-positive and -negative individuals.

Methods: This study was a retrospective analysis of patients diagnosed with constrictive pericarditis at Inkosi Albert Luthuli Central Hospital, Durban, over a 10-year period (2004-2014).

Results: Of 83 patients with constrictive pericarditis, 32 (38.1%) were HIV positive. Except for pericardial calcification, which was more common in HIV-negative subjects (n = 15, 29.4% vs n = 2, 6.3%; p = 0.011), the clinical profile was similar in the two groups. Fourteen patients died preoperatively (16.9%) and three died peri-operatively (5.8%). On multivariable analysis, age (OR 1.17; 95% CI: 1.03-1.34; p = 0.02), serum albumin level (OR 0.63; 95% CI: 0.43-0.92; p = 0.016), gamma glutamyl transferase level (OR 0.97; 95% CI: 0.94-0.1.0; p = 0.034) and pulmonary artery pressure (OR 1.49; 95% CI: 1.07-2.08; p = 0.018) emerged as independent predictors of pre-operative mortality rate. Peri-operative complications occurred more frequently in HIV-positive patients [9 (45%) vs 6 (17.6%); p = 0.030].

Conclusions: Without surgery, tuberculous constrictive pericarditis was associated with a high mortality rate. Although peri-operative complications occurred more frequently, surgery was not associated with increased mortality rates in HIV-positive subjects.

Keywords: HIV; constrictive pericarditis; pericardiectomy.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Early outcome of patients with constrictive pericarditis (CP).
Fig. 2
Fig. 2
Comparison of pre-operative and six-week postoperative New York Heart Association functional class status in 41 patients (p < 0.0001). Most subjects improved by at least one functional class. NYHA, New York Heart Association.
See this image and copyright information in PMC

References

    1. Ling LH, Oh JK, Schaff HV, Danielson GK, Mahoney DW, Seward JB. et al. Constrictive pericarditis in the modern era: evolving clinical spectrum and impact on outcome after pericardiectomy. Circulation. 1999;100(13):1380–1386. - PubMed
    1. Mutyaba AK, Balkaran S, Cloete R, du Plessis N, Badri M, Brink J. et al. Constrictive pericarditis requiring pericardiectomy at Groote Schuur Hospital, Cape Town, South Africa: Causes and perioperative outcomes in the HIV era (1990–2012). J Thorac Cardiovasc Surg. 2014;148(6):3058–65. e1. - PubMed
    1. Nishimura RA. Constrictive pericarditis in the modern era: a diagnostic dilemma. Heart. 2001;86(6):619–623. - PMC - PubMed
    1. Maisch B, Seferovi PM, Risti AD, ErbelR, Rienmuller R, Adler Y. et al. Guidelines on the diagnosis and management of pericardial diseases executive summary. The task force on the diagnosis and management of pericardial diseases of the European Society of Cardiology. Eur Heart J. 2004;25(7):587–610. - PubMed
    1. Myers RB, Spodick DH. Constrictive pericarditis: clinical and pathophysiologic characteristics. Am Heart J. 1999;138(2 Pt 1):219–232. - PubMed

Publication types

MeSH terms