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Meta-Analysis
. 2019 Aug 30;14(8):e0221166.
doi: 10.1371/journal.pone.0221166. eCollection 2019.

The effects of action observation training on improving upper limb motor functions in people with stroke: A systematic review and meta-analysis

Bingbing Zhang  1   2 , Laidi Kan  1 , Anqin Dong  1 , Jiaqi Zhang  3 , Zhongfei Bai  3   4 , Yi Xie  5 , Qianhao Liu  1 , Yuzhong Peng  1
Affiliations
Meta-Analysis

The effects of action observation training on improving upper limb motor functions in people with stroke: A systematic review and meta-analysis

Bingbing Zhang et al. PLoS One. .

Abstract

Background and objective: Action observation training (AOT) has been used as a new intervention for improving upper limb motor functions in people with stroke. This systematic review and meta-analysis aims to investigate the effects of AOT on improving upper limb motor functions in people with stroke.

Methods: We searched ten electronic databases to identify randomized controlled trials (RCTs) about the effects of AOT on upper limb motor functions in stroke survivors. Methodological quality of included studies was assessed by the Risk of Bias Tool in the Cochrane Handbook for Systematic Reviews of Interventions. A random-effects meta-analysis was performed by pooling the standardized mean difference (SMD) of upper limb motor outcomes.

Results: Seven studies of 276 participants with stroke were included. Meta-analysis showed a significant effect favoring AOT on improving upper limb motor functions in patients with stroke [SMD = 0.35, 95% confidence interval [CI], 0.10 to 0.61, I2 = 10.14%, p = 0.007].

Conclusions: AOT appears to be an effective intervention for improving the upper limb motor functions in people after stroke. Further studies need to investigate the neural mechanism underlying the effects of AOT.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of literature search and recruitment process.
Fig 2
Fig 2. Effects of AOT on upper limb motor functions in patients with stroke.
Fig 3
Fig 3. Subgroup analysis of task-based AOT and movement-based AOT.
Fig 4
Fig 4. Subgroup analysis of characteristics of stroke.
Fig 5
Fig 5. Publication bias.
Fig 6
Fig 6. Sensitivity analysis.
Fig 7
Fig 7. Assessment methodological quality of RCTs.
See this image and copyright information in PMC

References

    1. Mendis S. Stroke disability and rehabilitation of stroke: World Health Organization perspective. Int J stroke. 2013;8(1):3–4. Epub 2013/01/03. 10.1111/j.1747-4949.2012.00969.x . - DOI - PubMed
    1. Kwakkel G, Kollen BJ, van der Grond J, Prevo AJ. Probability of regaining dexterity in the flaccid upper limb: impact of severity of paresis and time since onset in acute stroke. Stroke. 2003;34(9):2181–6. Epub 2003/08/09. 10.1161/01.STR.0000087172.16305.CD . - DOI - PubMed
    1. Broeks JG, Lankhorst GJ, Rumping K, Prevo AJ. The long-term outcome of arm function after stroke: results of a follow-up study. Disabil Rehabil. 1999;21(8):357–64. Epub 1999/09/30. . - PubMed
    1. Corbetta D, Sirtori V, Castellini G, Moja L, Gatti R. Constraint-induced movement therapy for upper extremities in people with stroke (Cochrane review) [with consumer summary]. Cochrane Database Syst Rev 2015;Issue 10. 2015. - PMC - PubMed
    1. Cameirao MS, Badia SB, Duarte E, Frisoli A, Verschure P. The combined impact of virtual reality neurorehabilitation and its interfaces on upper extremity functional recovery in patients with chronic stroke. Stroke 2012. October;43(10):2720–2728. 2012. 10.1161/STROKEAHA.112.653196 - DOI - PubMed