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. 2019 Oct 1:484:107778.
doi: 10.1016/j.carres.2019.107778. Epub 2019 Aug 14.

Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels

Le Duc Dat  1 , Nguyen Thi Minh Tu  2 , Ngo Viet Duc  3 , Bui Thi Thuy Luyen  4 , Chu Thi Thanh Huyen  5 , Hyun Jae Jang  6 , Dang Thi Thu  7 , Tran Thu Huong  8 , Le Huyen Tram  9 , Nguyen Van Thong  10 , Nguyen Duc Hung  11 , Young Ho Kim  12 , Nguyen Phuong Thao  13
Affiliations

Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels

Le Duc Dat et al. Carbohydr Res. .

Abstract

A phytochemical investigation for the constituents of the stems of Millettia dielsiana Harms ex Diels resulted in the isolation of a new isoflavone glycoside, mildiside A (1), and 14 known compounds (2-15). Their chemical structures were determined using a combination of IR, NMR, MS, and optical rotation analysis, as well as comparison with the literature data. The ethanolic (EtOH) extract and several isolated compounds exert the inflammatory effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells.

Keywords: Anti-inflammatory effect; Leguminosae; Mildiside A; Millettia dielsiana; Phenolic compound.

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