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. 2019 Aug 30;20(1):54.
doi: 10.1186/s40360-019-0332-8.

Effect of green tea on the gastrointestinal absorption of amoxicillin in rats

Tivadar Kiss  1   2 , Zoltán Timár  3 , Andrea Szabó  2   4 , Anita Lukács  2   4 , Viktória Velky  3 , Gábor Oszlánczi  2   4 , Edina Horváth  4 , István Takács  1 , István Zupkó  2   5 , Dezső Csupor  6   7
Affiliations

Effect of green tea on the gastrointestinal absorption of amoxicillin in rats

Tivadar Kiss et al. BMC Pharmacol Toxicol. .

Abstract

Background: The investigation of food-drug and plant-drug interactions has become increasingly important. In case of antibiotics, it is essential to achieve and maintain a plasma concentration sufficient for the antimicrobial action. Although, on theoretical basis, the interaction of polyphenols and antibiotics may be hypothesized, experimental data are lacking to assess its clinical relevance. The aim of our study was to assess the interaction between one of the most widely used antibiotics, amoxicillin, and green tea, the most frequently consumed drink with high polyphenol content.

Methods: The effects of green tea on the plasma level of amoxicillin was studied in an in vivo experiment in rats. The plasma level of amoxicillin was monitored by LC-MS/MS for 240 min after oral administration. The polyphenol content of green tea was determined by the Folin-Ciocalteu method.

Results: The peak plasma concentration of amoxicillin significantly decreased upon its co-administration with green tea, although the AUC0-240 of the antibiotic did not decrease significantly in the group treated with amoxicillin suspended in green tea.

Conclusions: Our results suggest a potentially relevant interaction between green tea and amoxicillin, worth being further studied in humans.

Keywords: Amoxicillin; green tea; Camellia sinensis; Interaction; LC-MS/MS; Pharmacokinetics.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Change in the plasma concentration of amoxicillin in the AM and AMG groups. Data are shown as mean ± SEM (*p < 0.05)
Fig. 2
Fig. 2
AUC values in the AM and AMG groups. Data are shown as mean ± SEM
See this image and copyright information in PMC

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