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Review
. 2019 Oct;30(4):473-482.
doi: 10.1016/j.nec.2019.05.006. Epub 2019 Aug 7.

Management of Nonfunctioning Recurrent Pituitary Adenomas

Christopher J Farrell  1 , Tomas Garzon-Muvdi  2 , Judd H Fastenberg  3 , Gurston G Nyquist  3 , Mindy R Rabinowitz  3 , Marc R Rosen  3 , James J Evans  2
Affiliations
Review

Management of Nonfunctioning Recurrent Pituitary Adenomas

Christopher J Farrell et al. Neurosurg Clin N Am. 2019 Oct.

Abstract

Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.

Keywords: KNOSP grade; Pituitary adenomas; Recurrent pituitary tumor; Transsphenoidal surgery.

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