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Editorial
. 2019 Oct:60:vi-ix.
doi: 10.1016/j.coi.2019.07.009. Epub 2019 Aug 27.

Editorial overview: Attrition warfare: host cell weapons against intracellular pathogens, and how the pathogens fight back

Christina L Stallings  1 , Michael S Glickman  2
Affiliations
Editorial

Editorial overview: Attrition warfare: host cell weapons against intracellular pathogens, and how the pathogens fight back

Christina L Stallings et al. Curr Opin Immunol. 2019 Oct.
No abstract available

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Conflict of interest statement

Conflict of Interest

MG reports receiving consulting fees and equity from Vedanta Biosciences and receiving consulting fees from Takeda.

Figures

None
Mechanisms of antimicrobial defense highlighted in Host Pathogens 2019.
Four cell types are pictured: phagocyte (purple), neutrophil (pink), neuron, and T cell (red). Each number refers to a distinct pathway of antibacterial defense highlighted in the issue, as follows: 1: Host Inflammasome and bacterial evasion 2: NLRP1 Inflammasome 3: Metabolic reprogramming as a cellular defense mechanism 4: Hif1α in cellular resistance to intracellular pathogens 5: Reactive Oxygen 6: Reactive Nitrogen Intermediates 7: Metals as antimicrobial effectors 8: LC3 associated phagocytosis 9: IFN regulated GTPases 10: Apoptosis as cellular defense mechanism 11: Neutrophil effector mechanisms 12: Perforin-Granzyme mediated killing of intracellular pathogens 13:. Neurons in immune defense
See this image and copyright information in PMC

References

    1. Brewer SM, Brubaker SW, Monack DM: Host inflammasome defense mechanisms and bacterial pathogen evasion strategies. Curr Opin Immunol 2019, 60:63–70. - PubMed
    1. Mitchell PS, Sandstrom A, Vance RE: The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries. Curr Opin Immunol 2019, 60:37–45. - PMC - PubMed
    1. Escoll P, Buchrieser C: Metabolic reprogramming: an innate cellular defence mechanism against intracellular bacteria? Curr Opin Immunol 2019, 60:117–123. - PubMed
    1. Knight M, Stanley S: HIF-1α as a central mediator of cellular resistance to intracellular pathogens. Curr Opin Immunol 2019, 60:111–116. - PMC - PubMed
    1. Nauseef WM: The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling. Curr Opin Immunol 2019, 60:130–140. - PMC - PubMed

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