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. 2020 Jan;79(1):161-163.
doi: 10.1136/annrheumdis-2019-215239. Epub 2019 Aug 30.

Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals

Zhiqiang Li #  1   2   3   4 , Hong-Lei Liu #  5 , Jianhua Chen  2   3   6 , Ting Zeng  7 , Lin He  2   4 , Meihang Li  8 , Cainan Luo  9 , Shuang Liu  10 , Ting-Ting Ding  11 , Kuerbanjiang Yimaiti  9 , Jialin Teng  5 , Xingwang Li  2 , Yonghe Ding  8 , Xiaobing Cheng  5 , Juan Zhou  2 , Junna Ye  5 , Jue Ji  2 , Yu-Tong Su  5 , Hui Shi  5 , Yue Sun  5 , Chengwen Gao  8 , Qiongyi Hu  5 , Huihui Chi  5 , Xuan Yuan  12 , Zhuochao Zhou  5 , Dong Wang  2 , Ke Wang  2 , Chang-Gui Li  12 , Yuanchao Sun  8 , Yujuan Niu  8 , Lin-Jie Chen  11 , Jian Xu  10 , Lijun Wu  9 , Zhaowei Zhou  2 , Dun Pan  2 , Haitao Niu  1   13   14 , Yongyong Shi  1   2   3   4   6   15   16 , Chengde Yang  17
Affiliations

Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals

Zhiqiang Li et al. Ann Rheum Dis. 2020 Jan.
No abstract available

Keywords: Adult Onset Still's Disease; Gene Polymorphism; Inflammation.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Regional association plots of the adult-onset Still's disease-associated HLA class I and II regions. (A) HLA class II region and (B) HLA class I region. Purple circles represent the most significantly associated single nucleotide polymorphisms (SNPs) (marker SNPs) in each region in the meta-analysis of discovery and replication. −log10p values (Y-axis) of the SNPs (within the regions spanning 500 kb on either side of the marker SNP) are presented according to the chromosomal positions of the SNPs (X-axis, hg19). SNPs are coloured according to their linkage disequilibrium (LD) with the marker SNP. The LD values were established based on the 1000 Genomes Asian (ASI) Data (March 2012). Estimated recombination rates with samples from the 1000 Genomes Project March 2012 release are shown as blue lines, and the genomic locations of genes within the regions of interest annotated from the University of California, Santa Cruz (UCSC) genome browser are shown as arrows.
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References

    1. Giacomelli R, Ruscitti P, Shoenfeld Y. A comprehensive review on adult onset still's disease. J Autoimmun 2018;93:24–36. 10.1016/j.jaut.2018.07.018 - DOI - PubMed
    1. Feist E, Mitrovic S, Fautrel B. Mechanisms, biomarkers and targets for adult-onset Still’s disease. Nat Rev Rheumatol 2018;14:603–18. 10.1038/s41584-018-0081-x - DOI - PMC - PubMed
    1. Asano T, Furukawa H, Sato S, et al. . Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease. Arthritis Res Ther 2017;19 10.1186/s13075-017-1406-x - DOI - PMC - PubMed
    1. Ombrello MJ, Remmers EF, Tachmazidou I, et al. . HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proc Natl Acad Sci U S A 2015;112:15970–5. 10.1073/pnas.1520779112 - DOI - PMC - PubMed
    1. Sighart R, Rech J, Hueber A, et al. . Evidence for genetic overlap between adult onset Still's disease and hereditary periodic fever syndromes. Rheumatol Int 2018;38:111–20. 10.1007/s00296-017-3885-0 - DOI - PubMed

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