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. 2020 Apr;105(4):e186-e189.
doi: 10.3324/haematol.2019.225177. Epub 2019 Aug 30.

Comparative evaluation of biological human leukocyte antigen DPB1 mismatch models for survival and graft- versus-host disease prediction after unrelated donor hematopoietic cell transplantation

Francesca Lorentino  1 , Nicoletta Sacchi  2 , Elena Oldani  3 , Valeria Miotti  4 , Alessandra Picardi  5   6 , Anna Maria Gallina  2 , Pietro Crivello  7 , Paolo Bernasconi  8 , Riccardo Saccardi  9 , Lucia Farina  10 , Fabio Benedetti  11 , Michela Cerno  4 , Anna Grassi  3 , Benedetto Bruno  12   13 , Francesca Patriarca  4 , Fabio Ciceri  1   14 , Katharina Fleischhauer  15   16 , Luca Vago  1   17 , Francesca Bonifazi  18
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Comparative evaluation of biological human leukocyte antigen DPB1 mismatch models for survival and graft- versus-host disease prediction after unrelated donor hematopoietic cell transplantation

Francesca Lorentino et al. Haematologica. 2020 Apr.
No abstract available

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Figures

Figure 1.
Figure 1.
Comparative stratification of donor-recipient pairs according to five different biological models of DPB1 permissiveness, and outcome associations for TCE4. (A) Classification of the 382 DPB1 mismatched pairs under analysis in this study, as permissive or low risk (green) or as non-permissive or high risk (red) group according to five different biological models of permissiveness, as described in the text. For the Expression model and the DP2/DP5 model, only pairs with single mismatches in the graft-versus-host (GvH) direction can be stratified, the others cannot be classified (grey). The model under investigation, and the relevant numbers in each category (green, red or grey) are indicated to the left and to the right of the panel, respectively. The bottom panels show Kaplan-Meier probabilities for overall survival (OS) (B), graft-versus-host disease-free relapse-free survival (GRFS) (C), and commorbidity index (CI) of non-relapse mortality (NRM) (D) and extensive chronic graft-versus-host disease (cGvHD) (E) stratified for functional DPB1 matching according to TCE4 model, with permissive and non-permissive groups represented by the red and black curves, respectively. TRM: transplant-related mortality; HCT: hematopoietic cell transplantation; y: years.
See this image and copyright information in PMC

References

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    1. Fleischhauer K, Shaw BE, Gooley T, et al. Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoi-etic-cell transplantation: a retrospective study. Lancet Oncol. 2012; 13(4):366–374. - PMC - PubMed
    1. Crocchiolo R, Zino E, Vago L, et al. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation. Blood. 2009; 114(7):1437–1444. - PubMed
    1. Pidala J, Lee SJ, Ahn KW, et al. Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation. Blood. 2014;124(16):2596–2606. - PMC - PubMed

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