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Review
. 2019 Sep-Oct;33(5):1425-1430.
doi: 10.21873/invivo.11620.

Pneumococcal Vaccination Strategies Among HIV-infected Adult Patients: A Review of the Literature

Anna Garmpi  1 , Christos Damaskos  2 , Nikolaos Garmpis  2 , Alexandros Patsouras  3 , Spyridon Savvanis  4 , Nikolaos Gravvanis  5 , Evangelos Diamantis  6
Affiliations
Review

Pneumococcal Vaccination Strategies Among HIV-infected Adult Patients: A Review of the Literature

Anna Garmpi et al. In Vivo. 2019 Sep-Oct.

Abstract

Background/aim: Streptococcus pneumoniae is the leading cause of bacterial pneumonia and an important cause of invasive disease. Despite the antiretroviral therapies, adults infected with human immunodeficiency virus (HIV) are at particular risk for invasive pneumococcal disease (IPD). The purpose of this study was to report the efficacy of the strategies currently being used in pneumococcal vaccination for HIV-infected adults.

Materials and methods: A literature search was performed through electronic databases, for original articles in English, from years 2000 to 2019. Clinical trials controlled or randomized, and cohort studies were included.

Results: While 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for immunocompromised patients, it has been reported that it is less suitable for HIV-infected patients. Recent guidelines have added pneumococcal conjugate vaccine (PCV) to the list of recommended vaccines.

Conclusion: Further studies are needed to determine the optimal vaccines and intervals for subsequent revaccinations during the lifetime.

Keywords: HIV; Pneumococcal; adult; review; vaccine.

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Conflict of interest statement

The Authors declare that there is no conflict of interest regarding this study.

Figures

Figure 1
Figure 1. Prisma flow diagram for study identification and selection.
See this image and copyright information in PMC

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