Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May;65(5):1277-1287.
doi: 10.1007/s10620-019-05777-2.

The "Leaky Gut": Tight Junctions but Loose Associations?

Daniel Hollander  1 , Jonathan D Kaunitz  2   3   4
Affiliations
Review

The "Leaky Gut": Tight Junctions but Loose Associations?

Daniel Hollander et al. Dig Dis Sci. 2020 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Endoscopic confocal microscopy of grossly normal ileal mucosa in a patient with Crohn’s disease previously injected intravenously with the small solute fluorescent tracer sodium fluorescein (376 Da). Arrowheads: a Normal, b cell junction enhancement, c fluorescein leak, d cell drop out. Reproduced with permission from [27]
Fig. 2
Fig. 2
Summary of pathways by which endotoxin is absorbed in the intestine (a) and colon (b). LPS: Lipopolysaccharide. TLR4: Toll-like receptor 4. SR-B1: Scavenger receptor class B, type I. Reproduced from [47] with permission
Fig. 3
Fig. 3
Transmission electron microscopic images of the entry of intact bacteria into M-cells overlying the Peyer’s patches in rabbit ileum. Isolated loops of ileum were incubated with a suspension of S. pneumoniæ R36a prior to harvesting the tissue. Caption from “a TEM image of a M-cell (M) from 30 min treated PP. The cell shows the typical morphology: short microvilli, many pinocytotic vesicles (arrowheads) in the apical cytoplasm and a lymphoid cell (LC) close to the gut lumen (L). Among the microvilli three S. pneumoniae (arrows) are present. × 1000. b Detail of a. The bacterial wall (arrowheads) appears intact without damaged areas. M = M-cell. × 36,360. c Apical portion of a M-cell (M) with some streptococci inside endosomes (arrows), from a 60 min treated PP. The M-cell protrudes into the intestinal lumen (L) and joins the adjacent columnar cells (C). × 7870. d Enlargement of the square in c. The pneumococcus shows some broken areas in its wall (arrowheads). × 77,780.” Reproduced from [61] with permission
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nagpal R, Yadav H. Bacterial translocation from the gut to the distant organs: an overview. Ann Nutr Metab. 2017;71:11–16. - PubMed
    1. Camilleri M Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019;68:1516–1526. - PMC - PubMed
    1. Quigley EM. Leaky gut—concept or clinical entity? Curr Opin Gastroenterol. 2016;32:74–79. - PubMed
    1. Deitch EA. Gut-origin sepsis: evolution of a concept. Surgeon. 2012;10:350–356. - PMC - PubMed
    1. Bhatia M, He M, Zhang H, et al. Sepsis as a model of SIRS. Front Biosci (Landmark. Ed). 2009;14:4703–4711. - PubMed

MeSH terms

Substances

LinkOut - more resources