Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Oct;21(10):1044-54.
doi: 10.1021/jm00208a008.

2-Pyrrolidinylideneureas, a new class of central nervous system agents

C R Rasmussen, J F Gardocki, J N Plampin, B L Twardzik, B E Reynolds, A J Molinari, N Schwartz, W W Bennetts, B E Price, J Marakowski

2-Pyrrolidinylideneureas, a new class of central nervous system agents

C R Rasmussen et al. J Med Chem. 1978 Oct.

Abstract

A series of N-aryl-N'-(1-methyl-2-pyrrolidinylidene)ureas was prepared and screened for pharmacological activity. Congeners possessing either phenyl or phenyl substituted with 4-nitro, 3-bromo, 3-chloro, 3-fluoro, and 3-methyl groups were found to demonstrate anxiolytic activity. 2,6-Disubstitution of the phenyl ring with methyl, chloro, and bromo imparted potent muscle-relaxant properties which appear to be centrally mediated. A significant separation of the anxiolytic and muscle-relaxant properties from other CNS activities, e.g., anticonvulsant, sedative, and hypnotic, was achieved.

PubMed Disclaimer

MeSH terms