Lots of Movement in Gut and Parkinson's Research
- PMID: 31473011
- DOI: 10.1016/j.tem.2019.08.001
Lots of Movement in Gut and Parkinson's Research
Abstract
A new mouse model of Parkinson's disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits in wild-type mice. These findings support the idea that the gut could be a starting point for PD.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.Neuron. 2019 Aug 21;103(4):627-641.e7. doi: 10.1016/j.neuron.2019.05.035. Epub 2019 Jun 26. Neuron. 2019. PMID: 31255487 Free PMC article.
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