doi: 10.1016/j.tcb.2019.08.002.
Epub 2019 Aug 28.
The Nucleolus as a Proteostasis Regulator
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- PMID: 31473054
- DOI: 10.1016/j.tcb.2019.08.002
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The Nucleolus as a Proteostasis Regulator
Trends Cell Biol.
2019 Nov.
Abstract
Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.
Keywords: chaperones; neurodegenerative diseases; nucleus; protein quality control.
Copyright © 2019 Elsevier Ltd. All rights reserved.
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