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. 2019 Nov;29(11):849-851.
doi: 10.1016/j.tcb.2019.08.002. Epub 2019 Aug 28.

The Nucleolus as a Proteostasis Regulator

Fatima Amer-Sarsour  1 , Avraham Ashkenazi  2
Affiliations

The Nucleolus as a Proteostasis Regulator

Fatima Amer-Sarsour et al. Trends Cell Biol. 2019 Nov.

Abstract

Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.

Keywords: chaperones; neurodegenerative diseases; nucleus; protein quality control.

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