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Review
. 2019 Oct:38:89-96.
doi: 10.1016/j.coviro.2019.07.011. Epub 2019 Aug 29.

Targeting HIV-1 proviral transcription

Alex Olson  1 , Binita Basukala  2 , Wilson W Wong  3 , Andrew J Henderson  4
Affiliations
Review

Targeting HIV-1 proviral transcription

Alex Olson et al. Curr Opin Virol. 2019 Oct.

Abstract

Despite the success of antiretroviral therapies, there is no cure for HIV-1 infection due to the establishment of a long-lived latent reservoir that fuels viral rebound upon treatment interruption. 'Shock-and-kill' strategies to diminish the latent reservoir have had modest impact on the reservoir leading to considerations of alternative approaches to target HIV-1 proviruses. This review explores approaches to target HIV-1 transcription as a way to block the provirus expression.

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Conflict of interest statement

CONFLICT OF INTERST STATEMENT

None of the listed authors present a conflict of interest or any financial association that influences the objectivity, integrity or interpretation of context of this manuscript.

References

    1. Churchill MJ, Deeks SG, Margolis DM, Siliciano RF, Swanstrom R: HIV reservoirs: what, where and how to target them. Nat Rev Microbiol 2016, 14:55–60. - PubMed
    1. Castro-Gonzalez S, Colomer-Lluch M, Serra-Moreno R: Barriers for HIV Cure: The Latent Reservoir. AIDS Res Hum Retroviruses 2018, 34:739–759. - PMC - PubMed
    1. Pitman MC, Lau JSY, McMahon JH, Lewin SR: Barriers and strategies to achieve a cure for HIV. Lancet HIV 2018, 5:e317–e328. - PMC - PubMed
    1. Sengupta S, Siliciano RF: Targeting the Latent Reservoir for HIV-1. Immunity 2018, 48:872–895. - PMC - PubMed
    1. Margolis DM, Archin NM: Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents. J Infect Dis 2017, 215:S111–S118. - PMC - PubMed

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