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Editorial
. 2019 Sep;104(9):1689-1691.
doi: 10.3324/haematol.2019.224188.

Stem cell factor: the bridge between bone marrow adipocytes and hematopoietic cells

Ziru Li  1 , Ormond A MacDougald  2
Affiliations
Editorial

Stem cell factor: the bridge between bone marrow adipocytes and hematopoietic cells

Ziru Li et al. Haematologica. 2019 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Bone marrow adipocytes influence the maintenance of hematopoietic stem cell (HSC) and hematopoiesis. Bone marrow cellularity is complex, but is mainly composed of hematopoietic cells and bone marrow adipocytes (BMA), which appear after birth and accumulate with age, obesity and irradiation. BMA originate from osterix-positive (+) progenitor cells and secret adiponectin, stem cell factor (SCF) and other functional factors. In this study, Zhang et al. have demonstrated that BMAT-derived SCF plays important roles in HSC maintenance and hematopoietic differentiation under baseline, aging and obese conditions. Deficiency of SCF in BMAT hinders the self-renewal of HSC by influencing the bone marrow microenvironment and hematopoiesis through unknown mechanisms. RBC: red blood cell; MPP: multipotent progenitor; CMP: common myeloid progenitor; MEP: megakaryocyte-erythrocyte progenitor; GMP: granulocyte-monocyte progenitor; CLP: common lymphoid progenitor.
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References

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