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. 2019 Aug 30;9(8):e030562.
doi: 10.1136/bmjopen-2019-030562.

Perfusion parameters and target values during extracorporeal cardiopulmonary resuscitation: a scoping review protocol

Lars Saemann  1   2 , Christine Schmucker  3 , Lisa Rösner  4 , Friedhelm Beyersdorf  4 , Christoph Benk  4
Affiliations

Perfusion parameters and target values during extracorporeal cardiopulmonary resuscitation: a scoping review protocol

Lars Saemann et al. BMJ Open. .

Abstract

Introduction: Extracorporeal cardiopulmonary resuscitation (eCPR) is increasingly applied in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) patients. Treatment results are promising, but the efficacy and safety of the procedure are still unclear. Currently, there are no recommended target perfusion parameters during eCPR, the lack of which could result in inadequate (re)perfusion. We aim to perform a scoping review to explore the current literature addressing target perfusion parameters, target values, corresponding survival rates and neurologic outcomes in OHCA and IHCA patients treated with eCPR.

Methods and analysis: To identify relevant research, we will conduct searches in the electronic databases MEDLINE, EMBASE, Social Science Citation Index, Social Science Citation Index Expanded and the Cochrane library. We will also check references of relevant articles and perform a cited reference research (forward citation tracking).Two independent reviewers will screen titles and abstracts, check full texts for eligibility and perform data extraction. We will resolve dissent by consensus, moderated by a third reviewer. We will include observational and controlled studies addressing target perfusion parameters and outcomes such as survival rates and neurologic findings in OHCA and IHCA patients treated with eCPR. Data extraction tables will be set up, including study and patients' characteristics, aim of study, details on eCPR including target perfusion parameters and reported outcomes. We will summarise the data using tables and figures (ie, bubble plot) to present the research landscape and to describe potential clusters and/or gaps.

Ethics and dissemination: An ethical approval is not needed. We intend to publish the scoping review in a peer-reviewed journal and present results on a scientific meeting.

Keywords: cardiac arrest; extracorporeal cardiopulmonary resuscitation; extracorporeal life support; extracorporeal membrane oxygenation; reanimation; scoping review.

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Conflict of interest statement

Competing interests: FB und CB are shareholder of Resuscitec GmbH.

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References

    1. Cheskes S, Schmicker RH, Rea T, et al. . The association between AHA CPR quality guideline compliance and clinical outcomes from out-of-hospital cardiac arrest. Resuscitation 2017;116:39–45. 10.1016/j.resuscitation.2017.05.003 - DOI - PubMed
    1. Hawkes C, Booth S, Ji C, et al. . Epidemiology and outcomes from out-of-hospital cardiac arrests in England. Resuscitation 2017;110:133–40. 10.1016/j.resuscitation.2016.10.030 - DOI - PubMed
    1. Kragholm K, Wissenberg M, Mortensen RN, et al. . Bystander efforts and 1-year outcomes in out-of-hospital cardiac arrest. N Engl J Med Overseas Ed 2017;376:1737–47. 10.1056/NEJMoa1601891 - DOI - PubMed
    1. Murakami Y, Iwami T, Kitamura T, et al. . Outcomes of Out‐of‐Hospital cardiac arrest by public location in the Public‐Access defibrillation era. J Am Heart Assoc 2014;3 10.1161/JAHA.113.000533 - DOI - PMC - PubMed
    1. Nolan JP, Soar J, Smith GB, et al. . Incidence and outcome of in-hospital cardiac arrest in the United Kingdom national cardiac arrest audit. Resuscitation 2014;85:987–92. 10.1016/j.resuscitation.2014.04.002 - DOI - PubMed

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