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Case Reports
. 2019 Sep 25;59(9):589-591.
doi: 10.5692/clinicalneurol.cn-001245. Epub 2019 Aug 30.

[Wilson's disease presenting as Asperger syndrome]

[Article in Japanese]
Kazuhiro Tomiyasu  1 , Takeo Oshima  1 , Masami Yoshii  1 , Hiromi Suzuki  1 , Joji Inamasu  2 , Manabu Izumi  3
Affiliations
Case Reports

[Wilson's disease presenting as Asperger syndrome]

[Article in Japanese]
Kazuhiro Tomiyasu et al. Rinsho Shinkeigaku. .

Abstract

A 24-year-old man, who had been treated for 3 years as Asperger syndrome in adolescence due to behavioral disturbances, lack of social awareness and inability to socialize, was referred to our hospital shortly after tremors developed. On the basis of clinical features, laboratory findings and the brain MRI, a diagnosis of Wilson's disease (WD) was made. WD was further confirmed by genetic testing (the mutation of ATP7B gene). He was started with trientine hydrochloride 500 mg/day, and after 1 year of follow-up, his psychiatric symptoms have improved. Since psychiatric symptoms may precede the neurological symptoms, the possibility of WD should be always considered in the differential diagnosis of psychiatric disorders in young adults.

Keywords: Asperger syndrome; Wilson’s disease; psychiatric symptom.

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