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. 2019 Aug 14:13:851.
doi: 10.3389/fnins.2019.00851. eCollection 2019.

Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

Yuexin Cai  1   2 , Jiahong Li  1   2 , Yanhong Chen  1   2 , Wan Chen  3 , Caiping Dang  4   5 , Fei Zhao  6   7 , Wenrui Li  1   2 , Guisheng Chen  1   2 , Suijun Chen  1   2 , Maojin Liang  1   2 , Yiqing Zheng  1   2
Affiliations

Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

Yuexin Cai et al. Front Neurosci. .

Abstract

This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.

Keywords: EEG; ISSNHL; functional connectivity; source localization; tinnitus.

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Figures

FIGURE 1
FIGURE 1
Standardized low-resolution brain electromagnetic tomography. Compared with the healthy group, the ISSNHL group had significantly decreased activity in the left frontal lobe for the alpha 2 frequency band. Labels L, R, A and P represent left, right, anterior and posterior, respectively. Labels S and I represent superior and inferior.
FIGURE 2
FIGURE 2
Decreased functional connectivity between temporal gyrus and supramarginal gyrus for the gamma 2 frequency band in the linear lagged connectivity and lagged coherence analysis for ISSNHL patients with tinnitus. Labels L, R, A and P represent the left, right, anterior and posterior, respectively.
FIGURE 3
FIGURE 3
Decreased functional connectivity between central cingulate gyrus and right frontal lobe for gamma 2 frequency band in the lagged phase analysis for ISSNHL patients with tinnitus. Labels L, R, A and P represent the left, right, anterior and posterior, respectively.
See this image and copyright information in PMC

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