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. 2019 Aug 16:10:571.
doi: 10.3389/fpsyt.2019.00571. eCollection 2019.

Association of Transfusion With Risks of Dementia or Alzheimer's Disease: A Population-Based Cohort Study

Shih-Yi Lin  1   2 , Wu-Huei Hsu  1   3 , Cheng-Chieh Lin  1   4 , Cheng-Li Lin  5   6 , Hung-Chieh Yeh  1 , Chia-Hung Kao  1   7   8
Affiliations

Association of Transfusion With Risks of Dementia or Alzheimer's Disease: A Population-Based Cohort Study

Shih-Yi Lin et al. Front Psychiatry. .

Abstract

Purpose: The association between neurodegenerative diseases and transfusion remains to be investigated. Methods: The study population comprised 63,813 patients who underwent a blood transfusion and 63,813 propensity score-matched controls between 2000 and 2010. Data were obtained from the Taiwan National Health Insurance Research Database, which is maintained by the National Health Research Institutes. A Cox regression analysis was conducted to elucidate the relationship between blood transfusions and the risk of dementia. Results: A multivariate Cox regression analysis of factors, such as age, sex, cardiovascular ischemia disease, and depression, revealed that patients who underwent a blood transfusion showed a 1.73-fold higher risk of dementia [95% confidence interval (CI) = 1.62-1.84] and a 1.37-fold higher risk of Alzheimer's disease (AD) [95% CI = 1.13-1.66] than those who did not. Patients who received a transfusion of washed red blood cells showed a 2.37-fold higher risk of dementia (95% CI = 1.63-3.44) than those who did not. Conclusion: Blood transfusion, especially transfusion of any type of red blood cells is associated with an increased risk of dementia.

Keywords: Alzheimer’s disease; Taiwan National Health Insurance Research Database; cohort study; dementia; transfusion.

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Figures

Figure 1
Figure 1
Cumulative incidence comparison of dementia for patients with (dashed line) or without (solid line) blood transfusion.
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