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. 2019 Aug 28;5(3):e92-e95.
doi: 10.1055/s-0039-1694704. eCollection 2019 Jul.

Gastrointestinal Stromal Tumors of Small Intestine

Tanweerul Huda  1 , Mahendra Pratap Singh  1
Affiliations

Gastrointestinal Stromal Tumors of Small Intestine

Tanweerul Huda et al. Surg J (N Y). .

Abstract

Gastrointestinal stromal tumor (GIST) is defined as mesenchymal tumors of the gastrointestinal tract expressing proto-oncogene protein CD117. They are the most common sarcomatous tumors of the gastrointestinal tract. GISTs are presumed to arise from interstitial cells of Cajal or gastrointestinal pacemaker cells which control gut motility. They have unpredictable biological behavior. Prognosis is dependent on tumor size as well as mitotic count. Radical surgical excision is the treatment of choice. They rarely metastasize to lymph nodes. Imatinib therapy is used as an adjuvant therapy. The follow-up of patients postsurgery is not standardized.

Keywords: CD117; CD34; PDGFRA; gastrointestinal stromal tumors; gastrointestinal tumor; imatinib; jejunal tumor.

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Conflict of interest statement

Conflict of Interest The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Contrast-enhanced computed tomography (CECT) showing jejunal gastrointestinal stromal tumor (GIST).
Fig. 2
Fig. 2
Gastrointestinal stromal tumor (GIST) in the jejunum as exophytic lesion.
Fig. 3
Fig. 3
Resected gastrointestinal stromal tumor (GIST) with 5 cm margin.
Fig. 4
Fig. 4
View of jejunum showing serosal breach.
Fig. 5
Fig. 5
Cut section of jejunum showing intact mucosa.
Fig. 6
Fig. 6
Photomicrograph showing spindle cells arranged in fascicles and interlacing bundles. Cells had oval to elongated vesicular to hyperchromatic nucleus with inconspicuous nucleoli and cytoplasm in moderate amount. Occasional mitosis, thin walled blood vessels. Interspersed in between the lesion cells are foci of hemorrhage and fibrin deposition.
See this image and copyright information in PMC

References

    1. Bailey L. Florida: T Francis; 2018. Short Practice of Surgery. 27th ed; pp. 1139–1140.
    1. Miettinen M, Lasota J, Sobin L H. Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature. Am J Surg Pathol. 2005;29(10):1373–1381. - PubMed
    1. Fletcher C D, Berman J J, Corless C et al.Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33(05):459–465. - PubMed
    1. Miettinen M, Monihan J M, Sarlomo-Rikala M et al.Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23(09):1109–1118. - PubMed
    1. Reith J D, Goldblum J R, Lyles R H, Weiss S W. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13(05):577–585. - PubMed