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. 2019 Oct;8(14):6458-6467.
doi: 10.1002/cam4.2516. Epub 2019 Sep 1.

Trends in intracranial meningioma incidence in the United States, 2004-2015

Dong-Dong Lin  1 , Jia-Liang Lin  2 , Xiang-Yang Deng  1 , Wei Li  1 , Dan-Dong Li  1 , Bo Yin  1 , Jian Lin  1 , Nu Zhang  1 , Han-Song Sheng  1
Affiliations

Trends in intracranial meningioma incidence in the United States, 2004-2015

Dong-Dong Lin et al. Cancer Med. 2019 Oct.

Abstract

Background: Meningioma incidence was reported to have risen substantially in the United States during the first decade of the 21st century. There are few reports about subsequent incidence trends. This study provides updated data to investigate trends in meningioma incidence by demographic and tumor characteristics at diagnosis in the United states from 2004 to 2015.

Methods: Trends in meningioma incidence were analyzed using data from the Surveillance, Epidemiology, and End Results-18 (SEER-18) registry database of the National Cancer Institute. The joinpoint program was used to calculate annual percent change (APC) in incidence rates.

Results: The overall incidence of meningioma increased by 4.6% (95% CI, 3.4-5.9) annually in 2004-2009, but remained stable from 2009 to 2015 (APC, 0; 95% CI, -0.8 to 0.8). Females (10.66 per 100 000 person-years) and blacks (9.52 per 100 000 person-years) had significant predominance in meningioma incidence. Incidence in many subgroups increased significantly up to 2009 and then remained stable until 2015. However, meningioma incidence in young and middle-aged people increased significantly throughout the entire time period from 2004 to 2015 (APC: 3.6% for <20-year-olds; 2.5% for 20-39-year-olds; 1.8% for 40-59-year-olds). The incidence of WHO II meningioma increased during 2011-2015 (APC = 5.4%), while the incidence of WHO III meningioma decreased during 2004-2015 (APC = -5.6%).

Conclusion: In this study, the incidence of meningioma was found to be stable in recent years. Possible reasons for this finding include changes in population characteristics, the widespread use of diagnostic techniques, and changes in tumor classification and risk factors in the US population.

Keywords: SEER; age-adjusted incidence; demographic and tumor characteristics; meningioma; trends.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Trends in annual meningioma incidence rates by demographic characteristics (2004‐2015). A, shows overall meningioma incidence rates, and incidence by sex. B, shows meningioma incidence rates by race. C, shows meningioma incidence rates by age groups. All rates are age‐adjusted to the 2000 US standard population. Abbreviations: AIAN, American Indian/Alaskan Native; API, Asian/Pacific Islander
Figure 2
Figure 2
Trends in annual meningioma incidence rates by tumor characteristics (2004‐2015). A, shows meningioma incidence rates by histologic type. B, shows meningioma incidence rates by WHO grade. C, shows meningioma incidence rates by tumor size. All rates are age‐adjusted to the 2000 US standard population. Hemangioblastic meningioma and Meningeal sarcomatosis were not shown due to <16 cases in the time interval
Figure 3
Figure 3
Percentage of known tumor size for meningioma patients by year of diagnosis. Percentages are showed inside the bars
Figure 4
Figure 4
Diagnostic confirmation of meningioma by year of diagnosis. Frequencies are listed inside the bars
See this image and copyright information in PMC

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