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. 1988 Sep;70(9):1245-50.
doi: 10.1016/0300-9084(88)90191-5.

A possible physiological function of pancreatic pro-colipase activation peptide in appetite regulation

C Erlanson-Albertsson  1 , A Larsson
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A possible physiological function of pancreatic pro-colipase activation peptide in appetite regulation

C Erlanson-Albertsson et al. Biochimie. 1988 Sep.

Abstract

Pancreatic pro-colipase activation peptide, a pentapeptide with the sequence VPDPR was found to significantly suppress food intake of 20 h fasted Sprague-Dawley rats in a dose-dependent way. A rat treated with pro-colipase-enriched pellets for 26 days showed decreased daily food intake and retarded growth, which were restored during a following period of regular feeding. Genetically obese Zucker rats (fa/fa) were found to contain a reduced content of pancreatic pro-colipase (60% reduction), whereas the pancreatic lipase content was normal. A physiological function of pancreatic pro-colipase activation peptide as an endogenous satiety signal is suggested.

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