What makes the hepatitis C virus evolve?
- PMID: 31478837
- PMCID: PMC6721787
- DOI: 10.7554/eLife.50148
What makes the hepatitis C virus evolve?
Abstract
Polymorphisms in the IFNL4 gene that affect both the presence and the form of the coded protein are associated with changes in the hepatitis C virus.
Keywords: Hepatitis C; genetics; genomics; host-pathogen interactions; human; infectious disease; innate immunity; interferon-lambda 4; microbiology; virus.
Conflict of interest statement
TO TRO'B: Co-inventor (with LP-O) on a patent for the IFN-λ4 protein held by the National Cancer Institute. RH No competing interests declared, LP LP-O: Co-inventor (with TRO'B) on a patent for the IFN-λ4 protein held by the National Cancer Institute.
Comment on
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Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes.Elife. 2019 Sep 3;8:e42542. doi: 10.7554/eLife.42542. Elife. 2019. PMID: 31478832 Free PMC article.
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Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.Elife. 2019 Sep 3;8:e42463. doi: 10.7554/eLife.42463. Elife. 2019. PMID: 31478835 Free PMC article.
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