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. 2019 Nov 1;173(11):1032-1040.
doi: 10.1001/jamapediatrics.2019.2825.

Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis

Niek B Achten  1   2 , Claus Klingenberg  3   4 , William E Benitz  5 , Martin Stocker  6 , Luregn J Schlapbach  7   8   9 , Eric Giannoni  10 , Robin Bokelaar  1 , Gertjan J A Driessen  11 , Petter Brodin  12 , Sabita Uthaya  13 , Annemarie M C van Rossum  14 , Frans B Plötz  1
Affiliations

Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis

Niek B Achten et al. JAMA Pediatr. .

Abstract

Importance: The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on the effectiveness and safety of the EOS calculator is essential to inform clinicians considering implementation.

Objective: To assess the association between management of neonatal EOS guided by the neonatal EOS calculator (compared with conventional management strategies) and reduction in antibiotic therapy for newborns.

Data sources: Electronic searches in MEDLINE, Embase, Web of Science, and Google Scholar were conducted from 2011 (introduction of the EOS calculator model) through January 31, 2019.

Study selection: All studies with original data that compared management guided by the EOS calculator with conventional management strategies for allocating antibiotic therapy to newborns suspected to have EOS were included.

Data extraction and synthesis: Following PRISMA-P guidelines, relevant data were extracted from full-text articles and supplements. CHARMS (Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling Studies) and GRADE (Grades of Recommendation, Assessment, Development and Evaluation) tools were used to assess the risk of bias and quality of evidence. Meta-analysis using a random-effects model was conducted for studies with separate cohorts for EOS calculator and conventional management strategies.

Main outcomes and measures: The difference in percentage of newborns treated with empirical antibiotics for suspected or proven EOS between management guided by the EOS calculator and conventional management strategies. Safety-related outcomes involved missed cases of EOS, readmissions, treatment delay, morbidity, and mortality.

Results: Thirteen relevant studies analyzing a total of 175 752 newborns were included. All studies found a substantially lower relative risk (range, 3%-60%) for empirical antibiotic therapy, favoring the EOS calculator. Meta-analysis revealed a relative risk of antibiotic use of 56% (95% CI, 53%-59%) in before-after studies including newborns regardless of exposure to chorioamnionitis. Evidence on safety was limited, but proportions of missed cases of EOS were comparable between management guided by the EOS calculator (5 of 18 [28%]) and conventional management strategies (8 of 28 [29%]) (pooled odds ratio, 0.96; 95% CI, 0.26-3.52; P = .95).

Conclusions and relevance: Use of the neonatal EOS calculator is associated with a substantial reduction in the use of empirical antibiotics for suspected EOS. Available evidence regarding safety of the use of the EOS calculator is limited, but shows no indication of inferiority compared with conventional management strategies.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr van Rossum reported receiving grants from Sophia Foundation and Coolsingel Foundation outside the submitted work. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Study Selection Process
Flowchart of search results and study selection. aStudies excluded because data set was used in early-onset sepsis calculator development.
Figure 2.
Figure 2.. Forest Plot Presenting Relative Risk for Use of Empirical Antibiotics
Data presented for before-after studies included in the meta-analysis. Data were pooled under the assumption of a random-effects Mantel-Haenszel model. EOS indicates early-onset sepsis.
See this image and copyright information in PMC

Comment in

References

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