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Review
. 2020 Feb;91(2):147-154.
doi: 10.1002/JPER.19-0352. Epub 2019 Oct 8.

Biologics-based regenerative technologies for periodontal soft tissue engineering

Lorenzo Tavelli  1 , Michael K McGuire  1   2   3 , Giovanni Zucchelli  1   4 , Giulio Rasperini  1   5 , Stephen E Feinberg  6 , Hom-Lay Wang  1 , William V Giannobile  1   7
Affiliations
Free article
Review

Biologics-based regenerative technologies for periodontal soft tissue engineering

Lorenzo Tavelli et al. J Periodontol. 2020 Feb.
Free article

Abstract

This manuscript provides a state-of-the-art review on the efficacy of biologics in root coverage procedures, including enamel matrix derivative, platelet-derived growth factor, platelet concentrates, and fibroblast-growth factor-2. The mechanism of action and the rationale for using biologics in periodontal plastic surgery, as well as their anticipated benefits when compared with conventional approaches are discussed. Although the clinical significance is still under investigation, preclinical data and histologic evidence demonstrate that biologic-based techniques are able to promote periodontal regeneration coupled with the provision of tooth root coverage.

Keywords: gingival recession; growth factors; periodontal; regeneration; soft tissue grafting; tissue engineering.

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References

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