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. 2019 Sep 3;9(1):12676.
doi: 10.1038/s41598-019-49179-w.

The pathohistological subtype strongly predicts survival in patients with ampullary carcinoma

Carolin Zimmermann  1 , Steffen Wolk  1 , Daniela E Aust  2   3 , Frieder Meier  2 , Hans-Detlev Saeger  1 , Florian Ehehalt  1 , Jürgen Weitz  1 , Thilo Welsch  1 , Marius Distler  4
Affiliations

The pathohistological subtype strongly predicts survival in patients with ampullary carcinoma

Carolin Zimmermann et al. Sci Rep. .

Abstract

Ampullary cancer represents approximately 6% of the malignant periampullary tumors. An early occurrence of symptoms leads to a 5-year survival rate after curative surgery of 30 to 67%. In addition to the tumor stage, the immunohistological subtypes appear to be important for postoperative prognosis. The aim of this study was to analyze the different subtypes regarding their prognostic relevance. A total of 170 patients with ampullary cancer were retrospectively analyzed between 1999 until 2016 after pancreatic resection. Patients were grouped according to their pathohistological subtype of ampullary cancer (pancreatobiliary, intestinal, mixed). Characteristics among the groups were analyzed using univariate and multivariate models. Survival probability was analyzed by the Kaplan-Meier method. An exact subtyping was possible in 119 patients. A pancreatobiliary subtype was diagnosed in 69 patients (58%), intestinal in 41 patients (34.5%), and a mixed subtype in 9 patients (7.6%). Survival analysis showed a significantly worse 5-year survival rate for the pancreatobiliary subtype compared with the intestinal subtype (27.5% versus 61%, p < 0.001). The mean overall survival of patients with pancreatobiliary, intestinal, and mixed subtype was 52.5, 115 and 94.7 months, respectively (p < 0.001). The pathohistological subtypes of ampullary cancer allows a prediction of the postoperative prognosis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Kaplan-Meier estimation of overall survival of subtypes of ampullary cancer.
See this image and copyright information in PMC

References

    1. Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW. Tumors of the ampulla of vater: histopathologic classification and predictors of survival. Journal of the American College of Surgeons. 2008;207:210–218. doi: 10.1016/j.jamcollsurg.2008.01.028. - DOI - PubMed
    1. Westgaard A, Pomianowska E, Clausen OP, Gladhaug IP. Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies? Annals of surgical oncology. 2013;20:430–439. doi: 10.1245/s10434-012-2603-0. - DOI - PubMed
    1. Howe JR, Klimstra DS, Moccia RD, Conlon KC, Brennan MF. Factors predictive of survival in ampullary carcinoma. Annals of surgery. 1998;228:87–94. doi: 10.1097/00000658-199807000-00013. - DOI - PMC - PubMed
    1. Kim WS, et al. Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer. Journal of surgical oncology. 2012;105:266–272. doi: 10.1002/jso.22090. - DOI - PubMed
    1. Albores-Saavedra J, Schwartz AM, Batich K, Henson DE. Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program. Journal of surgical oncology. 2009;100:598–605. doi: 10.1002/jso.21374. - DOI - PubMed