Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Oct;16(5):404-413.
doi: 10.1007/s11904-019-00460-7.

HIV and Solid Organ Transplantation: Where Are we Now

Jean Botha  1 , June Fabian  1 , Harriet Etheredge  1 , Francesca Conradie  2 , Caroline T Tiemessen  3   4
Affiliations
Review

HIV and Solid Organ Transplantation: Where Are we Now

Jean Botha et al. Curr HIV/AIDS Rep. 2019 Oct.

Abstract

Purpose of review: We review the international evolution of HIV and solid organ transplantation over 30 years. We emphasise recent developments in solid organ transplantation from HIV-infected to HIV-uninfected individuals, and their implications.

Recent findings: In 2017, Johannesburg, South Africa, a life-saving partial liver transplant from an HIV-infected mother to her HIV-uninfected child was performed. This procedure laid the foundation not only for consideration of HIV-infected individuals as living donors, but also for the possibility that HIV-uninfected individuals could receive organs from HIV-infected donors. Recent advances in this field are inclusion of HIV-infected individuals as living organ donors and the possibility of offering HIV-uninfected individuals organs from HIV-infected donors who are well-controlled on combination antiretroviral therapy (cART). The large number of HIV-infected individuals on cART is an unutilised source of otherwise eligible living organ donors. HIV-positive-to-HIV-negative organ transplantation has become a reality, providing possible new therapeutic options to address extreme organ shortages.

Keywords: Antiretroviral therapy; HIV; HIV-positive-to-HIV-negative; Living donor; Solid organ transplantation; South Africa.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Timeline of key developments in the field of solid organ transplantation in the context of HIV infection. SOT, solid organ transplant; USA, United States of America; SA, South Africa; D, donor; R, recipient, −, HIV-negative; +, HIV-positive
See this image and copyright information in PMC

References

    1. Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341(23):1725–1730. doi: 10.1056/NEJM199912023412303. - DOI - PubMed
    1. Murray KF, Carithers RL., Jr AASLD. AASLD practice guidelines: evaluation of the patient for liver transplantation. Hepatology. 2005;41(6):1407–1432. doi: 10.1002/hep.20704. - DOI - PubMed
    1. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2012;14(8):803–869. doi: 10.1093/eurjhf/hfs105. - DOI - PubMed
    1. Merion RM, Pelletier SJ, Goodrich N, Englesbe MJ, Delmonico FL. Donation after cardiac death as a strategy to increase deceased donor liver availability. Ann Surg. 2006;244(4):555–562. - PMC - PubMed
    1. Feng S, Lai JC. Expanded criteria donors. Clin Liver Dis. 2014;18(3):633–649. doi: 10.1016/j.cld.2014.05.005. - DOI - PMC - PubMed

Substances