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Review
. 2019;15(4):101-110.
doi: 10.1080/15476278.2019.1656996. Epub 2019 Sep 4.

Advances of Wnt signalling pathway in dental development and potential clinical application

Xi Lu  1 , Jun Yang  1 , Shouliang Zhao  1 , Shangfeng Liu  1
Affiliations
Review

Advances of Wnt signalling pathway in dental development and potential clinical application

Xi Lu et al. Organogenesis. 2019.

Abstract

Wnt signalling pathway is widely studied in many processes of biological development, like embryogenesis, tissue homeostasis and wound repair. It is universally known that Wnt signalling pathway plays an important role in tooth development. Here, we summarized the function of Wnt signalling pathway during tooth initiation, crown morphogenesis, root formation, and discussed the therapeutic potential of Wnt modulators.

Keywords: Dentin regeneration; Wnt signalling; crown morphogenesis; root formation.

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Figures

FIGURE 1.
FIGURE 1.
Canonical and non-canonical Wnt signalling pathways known or needed to be proven to participate in rat tooth germ development.1,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75.
See this image and copyright information in PMC

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