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. 2019 Sep 2;63(5):509-515.
doi: 10.20945/2359-3997000000169. eCollection 2019.

The relationships between hemoglobin and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in adult Chinese

Yen-Shan Yang  1 , Chung-Ze Wu  2 , Jiunn-Diann Lin  2 , Chang-Hsun Hsieh  3 , Yen-Lin Chen  4 , Dee Pei  5 , Shi-Wen Kuo  6
Affiliations

The relationships between hemoglobin and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in adult Chinese

Yen-Shan Yang et al. Arch Endocrinol Metab. .

Abstract

Objective: We denote the four major factors related to the development of type 2 diabetes (T2D) as "diabetes factor" (DF); increased insulin resistance (IR); decreased glucose effectiveness (GE); and the first-and-second-phase of insulin secretion (FPIS, SPIS). The level of hemoglobin (Hb) was found to be related to IR and FPIS, but no-known studies focused on its role in relation to SPIS and GE. In this study, we aim to evaluate the relationships between Hb and all four DFs in the same individual.

Subjects and methods: We randomly enrolled 24,407 men and 24,889 women between 30 and 59 years old. IR, FPIS, SPIS and GE were measured according to equations published in our previous studies. To compare the slopes between Hb and the four DFs with different units, we converted their units to percent of change per unit of increased Hb.

Results: Age, HDL-cholesterol and GE were higher in women; BMI, blood pressure, LDL-cholesterol, TG, Hb, FPIS, SPIS and IR were higher in men. After they were converted into percentage, the closeness of their relationships to Hb, from the highest to the lowest, were GE, IR, FPIS and SPIS for women and IR, GE, FPIS and SPIS for men. GE was the only one negatively related to Hb.

Conclusions: Our data showed that IR, FPIS and SPIS were both positively and, GE negatively, related to the Hb in adult Chinese. For women, GE had the closest association with Hb; for men, it was IR. Both phases of insulin secretion had relatively weaker relationships than IR and GE.

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Conflict of interest statement

Disclosure: no potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. The comparison of the slopes between hemoglobin and diabetes factors in males and females.
See this image and copyright information in PMC

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References

    1. Nishtar S , Gluckman P , Armstrong T. Armstrong , Ending childhood obesity: a time for action . Lancet . 2016 ; 387 ( 10021 ): 825 - 7 . - PubMed
    1. Lin CC , Li CI , Hsiao CY , Liu CS , Yang SY , Lee CC , et al . Time trend analysis of the prevalence and incidence of diagnosed type 2 diabetes among adults in Taiwan from 2000 to 2007: a population-based study . BMC Public Health . 2013 ; 13 : 318 . - PMC - PubMed
    1. Jiang YD , Chang CH , Tai TY , Chen JF , Chuang LM . Incidence and prevalence rates of diabetes mellitus in Taiwan: analysis of the 2000-2009 Nationwide Health Insurance database . J Formos Med Assoc . 2012 ; 111 ( 11 ): 599 - 604 . - PubMed
    1. Huopio H , Otonkoski T , Vauhkonen I , Reimann F , Ashcroft FM , Laakso M . A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1 . Lancet . 2003 ; 361 ( 9354 ): 301 - 7 . - PubMed
    1. Grarup N , Moltke I , Albrechtsen A , Hansen T . Diabetes in population isolates: lessons from Greenland . Rev Diabet Stud . 2015 ; 12 ( 3-4 ): 320 - 9 . - PMC - PubMed