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Meta-Analysis
. 2019 Sep 4;14(9):e0221771.
doi: 10.1371/journal.pone.0221771. eCollection 2019.

Prevalence of extended-spectrum beta-lactamase producing bacteria from animal origin: A systematic review and meta-analysis report from India

Suresh P Kuralayanapalya  1 , Sharanagouda S Patil  1 , Sudhakar Hamsapriya  1 , Rajamani Shinduja  1 , Parimal Roy  1 , Raghavendra G Amachawadi  2
Affiliations
Meta-Analysis

Prevalence of extended-spectrum beta-lactamase producing bacteria from animal origin: A systematic review and meta-analysis report from India

Suresh P Kuralayanapalya et al. PLoS One. .

Abstract

Antimicrobial resistance (AMR) due to the emergence and spread of extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming a serious global public health concern. This article aims to assess the overall prevalence of ESBLs among animals in India, with year-wise, zone-wise and species-wise stratification. Systematic search from PubMed, Google Scholar and J-Gate Plus was carried out and 24 eligible articles from 2013-2019 in India were retrieved. The R Open source Scripting software was used to perform statistical analysis. The overall prevalence of ESBLs among animals in India was 9%. The pooled prevalence of ESBLs in animals were 26, 11, 6 and 8% for north, east, south and central zones, respectively. The reported prevalence of ESBLs in animals were 12, 5, 8, 8, 12, 13 and 33% were reported for the years 2013, 2014, 2015, 2016, 2017, 2018, 2019 respectively. The species-wise stratified results showed a predominance of ESBL producing Klebsiella pneumoniae strains (11%) when compared to Escherichia coli and Pseudomonas spp. which were 7% and 5%, respectively. The prevalence data generated could be utilized in infection control and in antibiotic use management decisions for developing appropriate intervention strategies.

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Conflict of interest statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Figures

Fig 1
Fig 1. The flow diagram of study selection process.
Fig 2
Fig 2. Forest plot of ESBL prevalence in India from 2013–2019.
Fig 3
Fig 3
Forest plots of ESBL prevalence in (a) 2013; (b) 2014; (c) 2015; (d) 2016; (e) 2017; (f) 2018; and (g) 2019.
Fig 4
Fig 4
Forest plots of ESBL prevalence in (a) north-zone; (b) east-zone; (c) south-zone; and (d) central-zone.
Fig 5
Fig 5. Forest plot of E. coli producing ESBL prevalence.
Fig 6
Fig 6. Forest plot of K. pneumonia producing ESBL prevalence.
Fig 7
Fig 7. Forest plot of Pseudomonas spp. producing ESBL prevalence.
See this image and copyright information in PMC

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