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. 2019 Sep 4;14(9):e0221788.
doi: 10.1371/journal.pone.0221788. eCollection 2019.

High-degree centrum semiovale-perivascular spaces are associated with development of subdural fluid in mild traumatic brain injury

Hae-Won Koo  1 , Minkyung Oh  2 , Hyung Koo Kang  3 , Yung Ki Park  1 , Byung-Jou Lee  1 , Seong Rok Han  1 , Sang Won Yoon  1 , Chan Young Choi  1 , Moon-Jun Sohn  1 , Chae Heuck Lee  1
Affiliations

High-degree centrum semiovale-perivascular spaces are associated with development of subdural fluid in mild traumatic brain injury

Hae-Won Koo et al. PLoS One. .

Abstract

Background: Severe centrum semiovale perivascular spaces (CSO-PVSs) are associated with the onset of brain atrophy and dementia. This study explored the relationship between severity of CSO-PVS and development of subdural fluid (SDF) in patients with mild traumatic brain injury (TBI), with the aim of investigating independent radiological risk factors for development of SDF.

Methods: The study cohort comprised 222 patients with a mean age of 51 years (64.0% men) who presented with mild TBI from January 2013 to November 2016. In this study, mild TBI was defined as a Glasgow Coma Scale (GCS) of ≥ 13, Post-Traumatic Amnesia (PTA) of <1 day, and Loss of Consciousness (LOC) of <30 minutes. The severity of CSO-PVS was categorized as low or high-degree.

Results: Among the 222 enrolled patients, 38 (17.1%) and 90 (40.5%) had high-degree PVS in the basal ganglia (BG) and centrum semiovale, respectively. Compared with patients who did not develop SDF, the mean age of patients who developed SDF was significantly higher (47.41 years versus 60.33 years, P < 0.0001). The incidence of de novo SDF was significantly higher in men than in women (77.8% versus 59.5%, P = 0.0151). Patients who showed SDF on brain computed tomography at admission more frequently developed de novo SDF (68.5% versus 38.1%, P < 0.0001). In multivariate logistic regression analysis of risk factors, high-degree CSO-PVS, male sex, initial SDF on admission, and old age were independently associated with development of de novo SDF after mild TBI. In Cox proportional hazards models of risk factors for SDF-development free survival rate, high-degree CSO-PVS, old age, and initial subdural hemorrhage showed statistically significant differences.

Conclusions: Our study might help neurosurgeons determine the frequency of brain CT or the duration of follow-up for patients who present with mild TBI with high-degree CSO-PVS.

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Conflict of interest statement

This work was funded by the Bio & Medical department of Hanmi medical company. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1
Subdural fluid-development free survival rate according to the severity of centrum semiovale perivascular space (CSO-PVS) (A), initial subdural hemorrhage (SDH) presence (B) and old age (C).
See this image and copyright information in PMC

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